Genomics

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Small RNA (sRNA) RNA-seq analysis of BORIS/CTCFL knockdown in K562 cell line


ABSTRACT: The study involved transcriptome analysis using RNA-seq knockdown of BORIS/CTCFL gene expression in K652 cancer cell line using inducible shRNA. The K562 cell line is the only cancer cell line that is known to be dependent on BORIS for proliferation and self-renewal of stemness. The goal of the study was to investigate the early/immediate small RNA transcriptional response to BORIS downregulation (over 10-fold reduction in protein level) using an inducible shRNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE99899 | GEO | 2017/09/25

SECONDARY ACCESSION(S): PRJNA389992

REPOSITORIES: GEO

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