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Effects of PPARgamma-inactive Delta-2-TGZ on breast cancer cells MCF-7

ABSTRACT: TGZ is an agonist of the nuclear receptor PPARgamma. This synthetic compound displays anticancer effects on breast cancer cells but some of them are PPARgamma independent. Delta-2-TGZ (delta-2-troglotazone) is a PPARgamma inactive TGZ derivative possessing a double bond adjoining the thiazolidinedione ring. This compound still displays anticancer efefcts. It is an interesting tool to study the PPARgamma-independent mechanisms. We used microarrays to examine the global programme of gene expression in response to Delta-2-TGZ treatment in MCF7 cell line.

ORGANISM(S): Homo sapiens

PROVIDER: GSE99941 | GEO | 2017/07/07

SECONDARY ACCESSION(S): PRJNA390157

REPOSITORIES: GEO

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