Dataset Information

GNPS - Viequeamides Cyclic Depsipeptides from a Rivularia sp.

ABSTRACT: Paper title: Viequeamide A, a Cytotoxic Member of the Kulolide Superfamily of Cyclic Depsipeptides from a Marine Button Cyanobacterium Author List: Boudreau PD, Byrum T, Liu WT, Dorrestein PC, Gerwick WH. Citation: J Nat Prod. 2012 Sep 28;75(9):1560-70. DOI: 10.1021/np300321b PubMedID: 22924493 Brief Description of Data Submitted: MS2 spectra of M+H of Viequeamides B-F collected on an LTQ-FT in either FT or LTQ mode. These spectra were used to determine the structures of Viequeamides C-F with comparison to the Viequeamide B NMR structure. Also uploaded are the MS2 spectra of M+Na of Viequeamide A and B from a low-resolution Thermo LCQ spectrometer (not used in this publication).

INSTRUMENT(S): LTQ Orbitrap, LTQ FT, Thermo LCQ Advantage Max

ORGANISM(S): Rivularia Sp.

SUBMITTER: William Gerwick

PROVIDER: MSV000078594 | GNPS | Wed Apr 16 14:01:00 BST 2014

REPOSITORIES: GNPS

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Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium.

Boudreau Paul D PD Byrum Tara T Liu Wei-Ting WT Dorrestein Pieter C PC Gerwick William H WH

Journal of natural products 20120827 9

The viequeamides, a family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, were isolated from a shallow subtidal collection of a "button" cyanobacterium (Rivularia sp.) from near the island of Vieques, Puerto Rico. Planar structures of the two major compounds, viequeamide A (1) and viequeamide B (2), were elucidated by 2D-NMR spectroscopy and mass spectrometry, whereas absolute configurations were determined by traditional hydrolysis, derivative formation, and ...[more]

PMID: 22924493

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