Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS_Steatohepatitis progresses to cancer via immunosuppression of HCC

ABSTRACT: Steatohepatitis progresses to cancer via immunosuppression of HCC

INSTRUMENT(S): maXis

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Karin

PROVIDER: MSV000080558 | GNPS | Tue Feb 21 12:04:00 GMT 2017

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Similar Datasets

GNPS_Steatohepatitis progresses to cancer via immunosuppression of HCC directed CD8+ T cells

Project description:Steatohepatitis progresses to cancer via immunosuppression of HCC directed CD8+ T cells LC/MS data of intestinal content in murine model. Multiple categories associated with normal and high fat diet, NAFLD, NASH and HCC are included.

2017-04-13 | MSV000080918 | GNPS

Myocardial Infarction accelerates breast cancer via innate immune reprogramming

Project description:Myocardial Infarction accelerates breast cancer via innate immune reprogramming

| PRJNA573069 | ENA

HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer

Project description:HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer

| PRJNA732187 | ENA

Neural invasion induces cachexia via astrocytic activation of neural route in pancreatic cancer

Project description:Pancreatic cancer is characterized by a high frequency of cachexia, pain and neural invasion (N-inv). Neural damage is occurred by N-inv and modulates pain and muscle atrophy via the activation of astrocyte in the connected spine. The activated astrocyte by N-inv, thus, may affect cachexia in pancreatic cancer. Clinical studies in patients and autopsy cases with pancreatic cancer have revealed that N-inv is related to cachexia and astrocytic activation. We established a novel murine model of cancer cachexia using N-inv of human pancreatic cancer cells. Mice with N-inv showed a loss of body weight, skeletal muscle, and fat mass without appetite loss, which are compatible with an animal model of cancer cachexia. Activation of astrocytes in the spinal cord connected with N-inv was observed in our model. Experimental cachexia was suppressed by disrupting neural routes or inhibiting the activation of astrocytes. These data provide the first evidence that N-inv induces cachexia via astrocytic activation of neural route in pancreatic cancer. We produced neural invasion (N-inv) model using intraneural injection of Capan-1 cells to left sciatic nerve of male SCID mouse. For controls, subcutaneous model (SC) and PBS model were produced. Microarray analysis was performed using the first lumbar cord (L1) from PBS, SC, and N-inv mice at 6 w (n = 2 each).

2011-12-07 | E-GEOD-34189 | biostudies-arrayexpress

Myocardial Infarction accelerates breast cancer via innate immune reprogramming (RNA-seq)

Project description:Myocardial Infarction accelerates breast cancer via innate immune reprogramming (RNA-seq)

| PRJNA558550 | ENA

Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement

Project description:Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement

| PRJNA268389 | ENA

Myocardial Infarction accelerates breast cancer via innate immune reprogramming (ATAC-seq)

Project description:Myocardial Infarction accelerates breast cancer via innate immune reprogramming (ATAC-seq)

| PRJNA573073 | ENA

Splicing factor SRSF1 promotes breast cancer progression via regulating alternative splicing

Project description:Splicing factor SRSF1 promotes breast cancer progression via regulating alternative splicing

| PRJNA684349 | ENA

Exosome-mediated radiosensitizing effect on neighboring cancer cells via exosomal microRNA

Project description:Exosome-mediated radiosensitizing effect on neighboring cancer cells via exosomal microRNA

| PRJNA685042 | ENA

KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression

Project description:KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression

| PRJNA722302 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data