Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS Grob DA 280 Column Test Mix

ABSTRACT: Grob DA 280 Column Test Mix Liquid Injection Split Ratios 100:1 & 10:1

INSTRUMENT(S): Agilent 7200 Series GC/Q-TOF

ORGANISM(S): N/a

SUBMITTER: Pieter Dorrestein

PROVIDER: MSV000082142 | GNPS | Fri Mar 09 10:55:00 GMT 2018

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

GNPS Grob DA 280 Column Test Mix & Fragrance GCMS Deconvolution Test Dataset

Project description:Grob DA 280 Column Test Mix Liquid Injection Split Ratios 100:1 & 10:1 and Restek Fragrance Materials Test Mix spectra obtained with liquid injection at two split ratios over five concentrations in triplicate

2018-03-21 | MSV000082192 | GNPS

GNPS_GC_Grob DA 280 Column Test Mix_resubmission

Project description:Grob DA 280 Column Test Mix Liquid Injection Split Ratios 100:1 & 10:1

2018-03-09 | MSV000082145 | GNPS

GNPS Fragrance GCMS Deconvolution Test Dataset

Project description:Restek Fragrance Materials Test Mix spectra obtained with liquid injection at two split ratios over five concentrations in triplicate

2018-03-19 | MSV000082182 | GNPS

Transcriptome profiling in 6-hydroxydopamine hemiparkinsonian rats reveals methamphetamine-mediated dopamine-independent changes in striatal gene expression.

Project description:Unilateral injections of 6-hydroxydopamine into the medial forebrain bundle (MFB) is used extensively as a model of Parkinson’s disease. The present experiments examined whether a single injection of methamphetamine (METH) (2.5 mg/kg) could still influence striatal gene expression after 6-hydroxydopamine (DA)-induced destruction of the nigrostriatal dopaminergic pathway in the rat. Unilateral injections of 6-hydroxydopamine into the MFB resulted in total striatal dopamine depletion on the lesioned side. This injection also caused decreased striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels. DA depletion was associated with increases in 5-HIAA/5-HT ratios which were potentiated by the METH injection. Microarray analyses revealed changes (+ 1.7-fold, p < 0.025) in the expression of 67 genes on the lesioned side in comparison to the intact side of the saline-treated hemiparkinsonian animals. These include follistatin, neuromedin U, and tachykinin 2 which were up-regulated. METH administration caused increases in the expression of several genes including c-fos, Egr1, and NOR-1 on the intact side. On the DA-depleted side, METH administration also increased the expression of 61 genes including Pdgfd and COX-2. There were METH-induced changes in 16 genes that were common in the DA-innervated and DA-depleted sides. These include c-fos and NOR-1 which show greater changes on the normal DA side. The present study documents METH-mediated DA-independent transcriptional alterations of several genes in the DA-denervated striatum. Our results also implicate serotonin as an important player in METH-induced gene expression because the METH injection also caused significant increases in 5-HIAA/5-HT ratios on the DA-depleted side.

2010-09-21 | GSE24233 | GEO