Dataset Information


GNPS - Expression of kava SPS1, SPS2, and CHS in Arabidopsis thaliana

ABSTRACT: Expression of kava SPS1, SPS2, and CHS in Arabidopsis thaliana tt4-2 background.


ORGANISM(S): Arabidopsis thaliana  

SUBMITTER: Jing-Ke Weng  

PROVIDER: MSV000083272 | GNPS | Fri Dec 21 06:56:00 GMT 2018


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The biosynthetic origin of psychoactive kavalactones in kava.

Pluskal Tomáš T   Torrens-Spence Michael P MP   Fallon Timothy R TR   De Abreu Andrea A   Shi Cindy H CH   Weng Jing-Ke JK  

Nature plants 20190722 8

Kava (Piper methysticum) is an ethnomedicinal shrub native to the Polynesian islands with well-established anxiolytic and analgesic properties. Its main psychoactive principles, kavalactones, form a unique class of polyketides that interact with the human central nervous system through mechanisms distinct from those of conventional psychiatric drugs. However, an unknown biosynthetic machinery and difficulty in chemical synthesis hinder the therapeutic use of kavalactones. In addition, kava also  ...[more]

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