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GNPS - Chemotyping of leaf and stem of 5 species of the genus Piper

ABSTRACT: Chemotyping of leaf and stem of 5 species of the genus Piper

OTHER RELATED OMICS DATASETS IN: MSV000083277MSV000083276

INSTRUMENT(S): Q Exactive

ORGANISM(S): Piper Auritum (ncbitaxon:130385) Piper Nigrum (ncbitaxon:13216) Piper Sarmentosum (ncbitaxon:405319) Piper Betle (ncbitaxon:13217) Piper Methysticum (ncbitaxon:130404)

SUBMITTER: Jing-Ke Weng

PROVIDER: MSV000083274 | GNPS | Sat Dec 22 06:30:00 GMT 2018

REPOSITORIES: GNPS

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The biosynthetic origin of psychoactive kavalactones in kava.

Pluskal Tomáš T Torrens-Spence Michael P MP Fallon Timothy R TR De Abreu Andrea A Shi Cindy H CH Weng Jing-Ke JK

Nature plants 20190722 8

Kava (Piper methysticum) is an ethnomedicinal shrub native to the Polynesian islands with well-established anxiolytic and analgesic properties. Its main psychoactive principles, kavalactones, form a unique class of polyketides that interact with the human central nervous system through mechanisms distinct from those of conventional psychiatric drugs. However, an unknown biosynthetic machinery and difficulty in chemical synthesis hinder the therapeutic use of kavalactones. In addition, kava also ...[more]

PMID: 31332312

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