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GNPS - Transient expression of SPS, KOMT1, and CYP719A26 from kava

ABSTRACT: Transient expression of SPS, KOMT1, and CYP719A26 from kava (Piper methysticum)

OTHER RELATED OMICS DATASETS IN: MSV000083277MSV000083276

INSTRUMENT(S): Q Exactive

ORGANISM(S): Nicotiana Benthamiana (ncbitaxon:4100)

SUBMITTER: Jing-Ke Weng

PROVIDER: MSV000083275 | GNPS | Sat Dec 22 06:39:00 GMT 2018

REPOSITORIES: GNPS

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The biosynthetic origin of psychoactive kavalactones in kava.

Pluskal Tomáš T Torrens-Spence Michael P MP Fallon Timothy R TR De Abreu Andrea A Shi Cindy H CH Weng Jing-Ke JK

Nature plants 20190722 8

Kava (Piper methysticum) is an ethnomedicinal shrub native to the Polynesian islands with well-established anxiolytic and analgesic properties. Its main psychoactive principles, kavalactones, form a unique class of polyketides that interact with the human central nervous system through mechanisms distinct from those of conventional psychiatric drugs. However, an unknown biosynthetic machinery and difficulty in chemical synthesis hinder the therapeutic use of kavalactones. In addition, kava also ...[more]

PMID: 31332312

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Transient expression of SPS, KOMT1, and CYP719A26 from kava

Project description:Transient expression of SPS, KOMT1, and CYP719A26 from kava (Piper methysticum)

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Expression data from human breast cancer cell MCF-7 and human gastric cancer cell SGC-7901

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Feature-based molecular networking in the GNPS analysis environment.

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GNPS Kava enzyme expression in Nicotiana benthamiana

Project description:The key enzymes of the kavalactone biosynthetic pathway from Piper methysticum were heterologuously expressed using agrobacterium infiltration in Nicotiana benthamiana. In addition, an isotopically labeled substrate, cinnamic acid-d6, was injected into the Nicotiana plants. Related to this study: Pluskal, T., Torrens-Spence, M.P., Fallon, T.R. et al. The biosynthetic origin of psychoactive kavalactones in kava. Nat. Plants 5, 867 (2019). https://doi.org/10.1038/s41477-019-0474-0

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