Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS Isothiocyanate Sesquiterpene Library

ABSTRACT: GNPS Isothiocyanate Sesquiterpene from Okinawan Marine Nudibranch

INSTRUMENT(S): Q-Tof ultima

ORGANISM(S): Phyllidiella (ncbitaxon:154615)

SUBMITTER: Viqqi Kurnianda

PROVIDER: MSV000085609 | GNPS | Thu Jun 18 17:43:00 BST 2020

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

GNPS - Pupukaenane library from Okinawan Marine Nudibranch

Project description:Isomeric 2 and 4-Pupukaenane library from Okinawan Marine Nudibranch

2020-06-18 | MSV000085610 | GNPS

GNPS Isothiocyanate Sesquiterpene References

Project description:GNPS Isothiocyanate Sesquiterpene References from Okinawan Nudibranchs

2020-06-18 | MSV000085603 | GNPS

GNPS Okinawan Marine Nudibranch Phyllidiella pustulosa

Project description:GNPS Phyllidiella pustulosa from Okinawan Nudibranch

2020-07-01 | MSV000085667 | GNPS

GNPs-pIL-4 reprograms macrophage polarization and activates the OSM/GSNOR/ENG axis to improve angiogenesis and tissue repair in murine ischemic limbs

Project description:Therapeutic angiogenesis based on gene therapies is a potential peripheral artery disease (PAD) treatment approach. Here, we developed a graphene nanoparticle-based IL-4 plasmid delivery system (GNPs-pIL-4) to reprogram macrophage polarization and activate the OSM/GSNOR/ENG axis to improve angiogenesis and tissue repair in ischemic limbs. Single-cell RNA sequencing analysis revealed that GNPs-pIL-4 treatment significantly enhanced the number and strength of intercellular communications in ischemic tissues, with enrichment of pathways associated with endothelial sprouting and neovascularization.

2026-07-03 | GSE327186 | GEO

Comparison between Nestin+ and Nestin- Ptch1 deficient GNPs

Project description:The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood. Here we report that Nestin binds the hedgehog pathway transcription factor Gli3 to mediate the development of medulloblastomas of the hedgehog subtype. In a mouse model system, Nestin levels increased progressively during medulloblastoma formation resulting in enhanced tumor growth. Conversely, loss of Nestin dramatically inhibited proliferation and promoted differentiation. Mechanistic investigations revealed that the tumor-promoting effects of Nestin were mediated by binding to Gli3, a zinc finger transcription factor that negatively regulates hedgehog signaling. Nestin binding to Gli3 blocked Gli3 phosphorylation and its subsequent proteolytic processing, thereby abrogating its ability to negatively regulate the hedgehog pathway. Our findings show how Nestin drives hedgehog pathway-driven cancers and uncover in Gli3 a therapeutic target to treat these malignancies. Nestin+ and Nestin- GNPs (granule neuron precursors) were purified from Nestin-CFP/Math1-Cre/Ptch1-loxp cerebella at postnatal day 4 by FACs, and total RNA from these two cell populations were extracted, and then labeled and hybridized to Affymetrix Mouse Genome 430 2.0 arrays.

2016-08-09 | E-GEOD-84392 | biostudies-arrayexpress

GNPS - Test for Nudibranch Works from Okinawan 2020

Project description:Test for Nudibranch Works from Okinawan Organisms 2020

2020-05-27 | MSV000085481 | GNPS

GNPS - Test for Nudibranch Works from Okinawan 2020

Project description:Test of Molecular Networking for Nudibranch Works from Okinawan 2020

2020-05-27 | MSV000085482 | GNPS

GNPS Test for Nudibranch Works from Okinawan 2020-2

Project description:Test for secondary metabolite of Nudibranch Works from Okinawan 2020-2

2020-05-27 | MSV000085485 | GNPS