Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GNPS Data to analyze the Lipidome of Mycobacterium tuberculosis H37Rv grown in zinc-replete and zinc-limited conditions

ABSTRACT: to analyze the lipidomes of Mycobacterium tuberculosis H37Rv grown in zinc-replete and zinc-limited conditions

INSTRUMENT(S): 6545 Q-TOF LC/MS

ORGANISM(S): Mycobacterium Tuberculosis H37rv (ncbitaxon:83332)

SUBMITTER: Philip G. Williams

PROVIDER: MSV000087030 | GNPS | Wed Mar 10 15:59:00 GMT 2021

REPOSITORIES: GNPS

ACCESS DATA

Json Xml

Similar Datasets

RNA-seq of suspension-grown vs. adherent Neisseria gonorrhoeae under conditions of zinc sequestration or zinc excess

Project description:Deep sequencing of cDNA of Neisseria gonorrhoeae bacteria that were grown in suspension or adherent to acid-washed glass coverslips, in media where zinc was sequestered or available in excess.

2022-12-12 | GSE191020 | GEO

Proteomics of Zinc-limited Mycobacterium tuberculosis

Project description:Mycobacterium tuberculosis H37Rv (Mtb) grown in chemically defined medium replete for Zinc and limited for Zinc

2021-04-23 | PXD024389 | Pride

SK14_Soybean: Proteomic and morphological analyses of soybean grown with sheet including zinc nanoparticles

Project description:Proteomic and morphological analyses of soybean grown with sheet including zinc nanoparticles

2023-08-28 | PXD031670 | JPOST Repository

A conserved nucleotide-dependent metal chaperone for managing the cellular zinc economy during zinc limitation

Project description:How cells safeguard essential zinc-dependent functions during zinc deficiency is poorly understood. A long-debated strategy is whether soluble metal-trafficking chaperones exist to prioritize specific zinc-dependent proteins. We identified a eukaryotic family of metallochaperones that physically interacts with zinc-dependent methionine aminopeptidase type I (MAP1) in human and yeast. Deletion of the yeast metallochaperone-encoding gene NMC1 (formerly YNR029c) leads to a zinc-deficiency growth defect and defective initiator methionine cleavage caused by loss of Map1p activity. To better understand the observed fitness defects due to the lack of NMC1 under zinc deficiency, we used proteomics with Tandem Mass Tag (TMT) quantitation derived from WT, nmc1Delta, and map2Delta nmc1Delta strains grown in zinc-limited (1 uM) or zinc-replete (100 uM) conditions. Proteomics reveal global impacts due to the loss of NMC1 and Map1p function, including mis-regulation of the Zap1p regulon, and suggests that Nmc1p is required to avoid a compounding effect of Map1p dysfunction on cell survival during zinc deficiency.

| MSV000088135 | MassIVE

Transcriptomics of Zinc-limited and Zinc-replete Mycobacterium tuberculosis

Project description:Transcriptomics of Zinc-limited and Zinc-replete Mycobacterium tuberculosis

| PRJNA707587 | ENA

Microarray of Aspergillus fumigatus wild type and ΔcrpA grown at different zinc concentrations.

Project description:Gene expression profiling of Aspergillus fumigatus comparing controls grown at normal zinc concentration of aspergillus minimum media (77uM), low (1uM) and high (500uM) zinc concentrations.

2019-08-15 | GSE135817 | GEO

Profiling of the Cellular Proteome and Phosphoproteome of Klebsiella pneumoniae under Zinc Limited and Zinc Replete Conditions

Project description:Klebsiella pneumoniae is a bacterial pathogen that causes nosocomial infection in humans and is acquiring antibiotic resistance at an alarming rate. This study investigates the effect of zinc limitation on the phosphoproteome of K. pneumoniae using quantitative mass spectrometry to provide insight into the cell signaling methods used to respond to nutrient limited conditions like those experienced when colonizing a host.

2023-03-23 | PXD041015 | Pride

Genome-wide expression analyses in Aspergillus fumigatus growing under alkaline zinc-limiting conditions

Project description:In this study it was investigated the role of ZafA on gene expression at a genome wide scale by comparing the transcriptional profile of a wild-type strain of A. fumigatus with that of a dzafA null strain grown in zinc-limiting media. The analysis of the results indicated that among genes up-regulated under zinc-limiting conditions were those most directly involved in zinc homeostasis such as zafA, that encoded for the ZafA transcriptional regulator of zinc homeostasis, zrfA, zrfB and zrfC that encoded zinc transporters presumably located at the plasma membrane and zrfF that encodes a zinc transporter located presumably at the vacuole membrane. Besides, a gene encoding a putative zinc-metallochaperone that might play a role in the correct folding of certain metalloproteins was also induced under zinc-limiting conditions. In addition, many other genes whose encoding products are either predicted or shown to be related to different metabolic or regulatory processes were also up-regulated under zinc-limiting conditions, including genes related to amino acid metabolism, cell wall biosynthesis, cytoskeletal assembly and reorganization, energy homeostasis, oxidative stress response, ER and vacuolar functions, iron metabolism, vesicular trafficking, lipid and ergosterol metabolism, protein degradation and modification, sulfur metabolism, ribosomal biogenesis and biosynthesis of secondary metabolites.

2018-01-19 | GSE109389 | GEO

Transcription profiling of fission yeast wild type and zinc regulatory null mutant grown in low zinc growth conditions

Project description:Transcription profile of low zinc growth condition in zinc regulatory null mutant

2008-02-22 | E-TABM-427 | biostudies-arrayexpress

Genome-wide association study of RegX3 in M. tuberculosis (Mtb) grown under phosphate limited conditions

Project description:Genome-wide association study of RegX3 in M. tuberculosis (Mtb) grown under phosphate limited conditions

| PRJNA757399 | ENA