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GNPS Workshop molecular network

ABSTRACT: Lotus leaf (Nelumbinis Folium) is a kind of common medicinal and edible homologous Chinese herbal medicine.Effective components from the lotus leaf mainly include alkaloids, flavonoids, volatile oils, polysaccharides, polyphenols, etc., in addition to steroid, fatty acid, protein, amino acids, trace elements and vitamins and other active ingredients, its pharmacological effects are also very wide, with a lipid diet, antibacterial, anti-inflammatory, antioxidant, regulate blood sugar, immune regulation and the selective inhibition of nerve excitement.In recent years, lotus leaf has attracted the attention of researchers at home and abroad. This paper, by collecting, sorting out and analyzing relevant literatures at home and abroad, summarizes the research status of the active components in lotus leaf and its pharmacological effects, so as to provide scientific basis and theoretical guidance for further development and utilization of lotus leaf.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Nelumbo Nucifera (ncbitaxon:4432)

SUBMITTER: Jason Maynard

PROVIDER: MSV000087148 | GNPS | Fri Apr 02 05:53:00 BST 2021

REPOSITORIES: GNPS

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Project description:Background: Supplementing farm animals diet with functional ingredients may improve the nutritional quality of meat products. Diet composition has been also demonstrated to influence the gene expression with effect on biological processes and pathways. However, the knowledge on the effect of nutrients at the molecular level is scant. In particular, studies on the effects of antioxidants and polyphenols dietary supplementation have been investigated mainly in rodents, and only scarcely in farm animals so far. RNA-seq with next-generation sequencing (NGS) is increasingly the method of choice for studying changes in the transcriptome and it has been recently employed also in pig nutrigenomics studies to identify diet-induced changes in gene expression. The present study aimed to investigate the effect of diets enriched with functional ingredients (linseed, vitamin E and plant extracts) on the transcriptome of pig Longissimus thoracis to elucidate the role of these compounds in influencing genes involved in muscle physiology and metabolism compared to a standard diet. Results: 893 significant differentially expressed genes (DEGs) (FDR adjusted P-value < 0.05) were detected by RNA-seq analysis in the three diet comparisons (D2-D1, D3-D1, D4-D1). The functional analysis of DEGs showed that the diet enriched with n-3 PUFA from linseed (D2) mostly downregulated genes, compared to the standard diet (D1) included in pathways and biological processes (BPs) involved in muscle development, contraction, and glycogen metabolism. The diet supplemented with linseed and vitamin E/Selenium (D3) compared to D1 mostly downregulated genes linked to oxidative phosphorylation. Only few genes were upregulated by the D3 and involved in extracellular matrix (ECM) organization. Finally, the comparison D4-D1 showed that the diet supplemented with linseed and plant extracts (D4) upregulated the majority of genes compared to D1 that were included in a complex network of pathways and BPs all connected by hub genes. In particular, IGF2 was a hub gene connecting protein metabolism, ECM organization, immune system and lipid biosynthesis pathways. Conclusion: The supplementation of pig diet with n-3 PUFA from linseed, antioxidants and plant-derived polyphenols can influence the expression of a relevant number of genes in Longissimus thoracis muscle that are involved a variety of biochemical pathways linked to muscle function and metabolism.

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GNPS Workshop molecular network

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