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GNPS Comparative metabolomics with Metaboseek reveals functions of peroxisomal alpha-oxidation in C. elegans

ABSTRACT: Helf MJ, Fox BW, Artyukhin AB, Zhang YK, Schroeder FC (2021) Comparative metabolomics with Metaboseek reveals functions of peroxisomal alpha-oxidation in C. elegans

INSTRUMENT(S): Q Exactive HF, Q Exactive

ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239)

SUBMITTER: Frank Schroeder

PROVIDER: MSV000087885 | GNPS | Mon Jul 26 13:36:00 BST 2021

REPOSITORIES: GNPS

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Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans.

Helf Maximilian J MJ Fox Bennett W BW Artyukhin Alexander B AB Zhang Ying K YK Schroeder Frank C FC

Nature communications 20220210 1

Untargeted metabolomics via high-resolution mass spectrometry can reveal more than 100,000 molecular features in a single sample, many of which may represent unidentified metabolites, posing significant challenges to data analysis. We here introduce Metaboseek, an open-source analysis platform designed for untargeted comparative metabolomics and demonstrate its utility by uncovering biosynthetic functions of a conserved fat metabolism pathway, α-oxidation, using C. elegans as a model. Metaboseek ...[more]

PMID: 35145075

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