Dataset Information
GNPS - Combining HPLC Activity Profiling with Advanced UPLC-HRMS/MS Annotation to Accelerate the Discovery of Bioactive Natural Products
Ontology highlight
ABSTRACT:
INSTRUMENT(S): ACQUITY UPLC I-Class, Q Exactive
ORGANISM(S): Condea Verticillata (ncbitaxon:986250) Artemisia Scoparia (ncbitaxon:72351) Artemisia Vulgaris (ncbitaxon:4220) Hyptis Capitata (ncbitaxon:204124) Artemisia Argyi (ncbitaxon:259893) Artemisia Absinthium (ncbitaxon:72332) Hyptis Brachiata (ncbitaxon:1125939) Hyptis Brevipes (ncbitaxon:204123)
SUBMITTER: 
Jean-Luc Wolfender
PROVIDER: MSV000088606 | GNPS | Wed Dec 22 23:48:00 GMT 2021
REPOSITORIES: GNPS
Publications
Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma.
Journal of natural products 20220531 6
The discovery of bioactive natural products remains a time-consuming and challenging task. The ability to link high-confidence metabolite annotations in crude extracts with activity would be highly beneficial to the drug discovery process. To address this challenge, HPLC-based activity profiling and advanced UHPLC-HRMS/MS metabolite profiling for annotation were combined to leverage the information obtained from both approaches on a crude extract scaled down to the submilligram level. This strat ...[more]
