Metabolomics

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GNPS Burkholderia thailandensis-exposed Murine Airway Epithelial and Murine Macrophage Cells and Monocultures

ABSTRACT: Extraction samples of murine airways epithelial LA-4 cells and murine macrophage RAW264.7 cells cultures exposed to different amounts of B. thailandensis for varying periods of time. Extracts of the adherent cells and their respective conditioned media were analyzed with LC-MS/MS to identify compounds detected within the aforementioned samples. Included are extracts of B. thailandensis monocultures, B. thailandensis-exposed LA-4 and RAW264.7 mammalian cells, and LA-4 and RAW264.7 unexposed monocultures.

INSTRUMENT(S): impact II

ORGANISM(S): Burkholderia Thailandensis E264 (ncbitaxon:271848) Murine Airway Epithelial La-4 Murine Macrophage Raw264.7

SUBMITTER: Neha Garg  

PROVIDER: MSV000088693 | GNPS | Mon Jan 17 13:46:00 GMT 2022

REPOSITORIES: GNPS

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Publications

Metabolomics Analysis of Bacterial Pathogen <i>Burkholderia thailandensis</i> and Mammalian Host Cells in Co-culture.

Aiosa Nicole N   Sinha Anupama A   Jaiyesimi Olakunle A OA   da Silva Ricardo R RR   Branda Steven S SS   Garg Neha N  

ACS infectious diseases 20220629 8

The Tier 1 HHS/USDA Select Agent <i>Burkholderia pseudomallei</i> is a bacterial pathogen that is highly virulent when introduced into the respiratory tract and intrinsically resistant to many antibiotics. Transcriptomic- and proteomic-based methodologies have been used to investigate mechanisms of virulence employed by <i>B. pseudomallei</i> and <i>Burkholderia thailandensis</i>, a convenient surrogate; however, analysis of the pathogen and host metabolomes during infection is lacking. Changes  ...[more]

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