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GNPS-Untargeted metabolomics of mangrove fungi_Tamihua_Verazcruz_Mexico

ABSTRACT: Untargeted metabolomics LC-MS/MS (positive mode) of fungal extracts obtained by an initial chloroform-methanol (1:1) extraction followed by water and hexane partitioned procedures of fungi grown on two different solid media; Cheerios cereal and rice.

INSTRUMENT(S): 6530B Q-TOF LC/MS

ORGANISM(S): Scytalidium (ncbitaxon:5538) Pestalotiopsis (ncbitaxon:37840) Curvularia (ncbitaxon:5502) Colletotrichum (ncbitaxon:5455) Westerdykella (ncbitaxon:45153) Scolecobasidium (ncbitaxon:37940) Aspergillus (ncbitaxon:5052) Diaporthe (ncbitaxon:36922) Gelasinospora (ncbitaxon:29880) Geosmithia <talaromyces> (ncbitaxon:39190) Nigrospora (ncbitaxon:114230) Trichoderma (ncbitaxon:5543) Neopestalotiopsis Sp. (ncbitaxon:1849553) Penicillium (ncbitaxon:5073)

SUBMITTER: Dr. Jose Alberto Rivera Chavez

PROVIDER: MSV000091237 | GNPS | Thu Feb 09 16:13:00 GMT 2023

REPOSITORIES: GNPS

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Publications

Integrating Taxonomic and Chemical Diversity of Mangrove-Associated Ascomycetes to Discover or Repurpose Bioactive Natural Products.

Martínez-Aldino Ingrid Y IY Rivera-Chávez José J Morales-Jiménez Jesús J

Journal of natural products 20231024 11

Natural product reisolation is a bottleneck when discovering new bioactive chemical entities from nature. To overcome this issue, multi-informative approaches integrating several layers of data have been applied with promising results. In this study, integration of taxonomy, nontargeted metabolomics, and bioactivity information resulted in the selection of Scytalidium sp. IQ-074 and Diaporthe sp. IQ-053 to isolate new natural products active against hPTP1B1-400 an ...[more]

PMID: 37875020

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