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GNPS - Bacterial Bile Acid Amidates (BBAAs) data set

ABSTRACT: Data acquired for conjugated bile acids with amino acids analysis of human fecal samples by targeted LC-MS. These samples are a part of a study investigating a new BSH function as an amine N-acyl transferase that conjugates amines to form bacterial bile acid amidates (BBAAs).

INSTRUMENT(S): TSQ Quantis

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: ANDREW DAVID Patterson

PROVIDER: MSV000093144 | GNPS | Wed Oct 18 08:48:00 BST 2023

REPOSITORIES: GNPS

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Bile salt hydrolase catalyses formation of amine-conjugated bile acids.

Rimal Bipin B Collins Stephanie L SL Tanes Ceylan E CE Rocha Edson R ER Granda Megan A MA Solanki Sumeet S Hoque Nushrat J NJ Gentry Emily C EC Koo Imhoi I Reilly Erin R ER Hao Fuhua F Paudel Devendra D Singh Vishal V Yan Tingting T Kim Min Soo MS Bittinger Kyle K Zackular Joseph P JP Krausz Kristopher W KW Desai Dhimant D Amin Shantu S Coleman James P JP Shah Yatrik M YM Bisanz Jordan E JE Gonzalez Frank J FJ Vanden Heuvel John P JP Wu Gary D GD Zemel Babette S BS Dorrestein Pieter C PC Weinert Emily E EE Patterson Andrew D AD

Nature 20240207 8000

Bacteria in the gastrointestinal tract produce amino acid bile acid amidates that can affect host-mediated metabolic processes1-6; however, the bacterial gene(s) responsible for their production remain unknown. Herein, we report that bile salt hydrolase (BSH) possesses dual functions in bile acid metabolism. Specifically, we identified a previously unknown role for BSH as an amine N-acyltransferase that conjugates amines to bile acids, thus forming bacterial bile acid amidates (BBAAs) ...[more]

PMID: 38326609

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