Impact of regulatory variation from RNA to protein

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD001406. Experiment: GM18519, MSB14195, file: GM18519_MSB14195_16.mzml. Published as part of Science 2014 Dec. 18 . From the Abstract: {{i}} ... we mapped genetic variants that are associated with eQTLs, ribosome occupancy (rQTLs), or protein abundance (pQTLs). We found that most QTLs are associated with transcript expression levels, with consequent effects on ribosome and protein levels. However, eQTLs tend to have significantly reduced effect sizes on protein levels, suggesting that their potential impact on downstream phenotypes is often attenuated or buffered ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Homo_sapiens_viruses, Human

DISEASE(S): Not Available

SUBMITTER: Battle A, et al.  

PROVIDER: GPM11210033257 | GPMDB |

REPOSITORIES: GPMDB