Ontology highlight
ABSTRACT:
INSTRUMENT(S): Instrument
ORGANISM(S): Homo_sapiens_viruses, Human
DISEASE(S): Not Available
SUBMITTER: Haiyan Tan, et al.
PROVIDER: GPM11210034774 | GPMDB |
REPOSITORIES: GPMDB
Tan Haiyan H Wu Zhiping Z Wang Hong H Bai Bing B Li Yuxin Y Wang Xusheng X Zhai Bo B Beach Thomas G TG Peng Junmin J
Proteomics 20141215 2-3
Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive loss of cognitive function. One of the pathological hallmarks of AD is the formation of neurofibrillary tangles composed of abnormally hyperphosphorylated tau protein, but global deregulation of protein phosphorylation in AD is not well analyzed. Here, we report a pilot investigation of AD phosphoproteome by titanium dioxide enrichment coupled with high resolution LC-MS/MS. During the optimization of the e ...[more]