Ontology highlight
ABSTRACT:
INSTRUMENT(S): Instrument
ORGANISM(S): Homo_sapiens_viruses, Human_female
DISEASE(S): Not Available
SUBMITTER: Xiao Z, et al.
PROVIDER: GPM32310018476 | GPMDB |
REPOSITORIES: GPMDB
Xiao Zhenyu Z Chang Jer-Gung JG Hendriks Ivo A IA Sigurðsson Jón Otti JO Olsen Jesper V JV Vertegaal Alfred C O AC
Molecular & cellular proteomics : MCP 20150309 5
Genotoxic agents can cause replication fork stalling in dividing cells because of DNA lesions, eventually leading to replication fork collapse when the damage is not repaired. Small Ubiquitin-like Modifiers (SUMOs) are known to counteract replication stress, nevertheless, only a small number of relevant SUMO target proteins are known. To address this, we have purified and identified SUMO-2 target proteins regulated by replication stress in human cells. The developed methodology enabled single st ...[more]