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Omics score: 1005

A Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues.

ABSTRACT: Data from ProteomeXchange, .PXD ID: PXD001724. Experiment: M35_003, file: folder summary. Published as part of PLoS One. 2015 Apr 13;10(4):e0123661 . From the Abstract: {{i}} ... The aim of the present study was to build a protein sequence database in metastatic melanoma, searching for novel, relevant biomarkers. Ten lymph node metastases (South-Swedish Malignant Melanoma Biobank) were subjected to global protein expression analysis using two proteomics approaches (with/without orthogonal fractionation).... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Homo_sapiens_viruses, Human

DISEASE(S): Not Available

SUBMITTER: Welinder C, et al.

PROVIDER: GPM32310019253 | GPMDB |

REPOSITORIES: GPMDB

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A protein deep sequencing evaluation of metastatic melanoma tissues.

Welinder Charlotte C Pawłowski Krzysztof K Sugihara Yutaka Y Yakovleva Maria M Jönsson Göran G Ingvar Christian C Lundgren Lotta L Baldetorp Bo B Olsson Håkan H Rezeli Melinda M Jansson Bo B Laurell Thomas T Fehniger Thomas T Döme Balazs B Malm Johan J Wieslander Elisabet E Nishimura Toshihide T Marko-Varga György G

PloS one 20150413 4

Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure. Recently, several protein kinase inhibitors and immune modifiers have shown promising clinical results but drug resistance in metastasized melanoma remains a major problem. The need for routine clinical biomarkers to follow disease progression and treatment efficacy ...[more]

PMID: 25874936

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