Super-SILAC allows classification of diffuse large B-cell lymphoma subtypes by their protein expression profiles.

ABSTRACT: Data from ProteomeXhchange, PXD ID: PXD002098. Experiment: TMD8(2), file: folder summary. Published as part of Mol Cell Proteomics. 2012 May;11(5):77-89 . From the Abstract: {{i}} ... Here we show that high accuracy, quantitative proteomics can robustly segregate cancer subtypes directly at the level of expressed proteins. We investigated two histologically indistinguishable subtypes of diffuse large B-cell lymphoma (DLBCL): activated B-cell-like (ABC) and germinal-center B-cell-like (GCB) subtypes, by first developing a general lymphoma stable isotope labeling with amino acids in cell culture (SILAC) mix from heavy stable isotope-labeled cell lines. This super-SILAC mix was combined with cell lysates from five ABC-DLBCL and five GCB-DLBCL cell lines ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Homo_sapiens_viruses, Human

DISEASE(S): Not Available

SUBMITTER: Deeb SJ, et al.  

PROVIDER: GPM32310019515 | GPMDB |

REPOSITORIES: GPMDB