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Omics score: 1007

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD001364. Experiment: AggregatesSILAC_DAF16_D01, file: 20110921_Velos3_DiWa_SA_Celegans_AggregatesSILAC_DAF16_D01-3.mzml. Published as part of Cell. 2015 May 7;161(4):919-932 . From the Abstract: {{i}} ... Here, we profiled more than 5, 000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during aging, resulting in a severe proteome imbalance ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Worm, Escherichia_coli_k_12_substr__mg1655

DISEASE(S): Not Available

SUBMITTER: Walther DM, et al.

PROVIDER: GPM32310019629 | GPMDB |

REPOSITORIES: GPMDB

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Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther Dirk M DM Kasturi Prasad P Zheng Min M Pinkert Stefan S Vecchi Giulia G Ciryam Prajwal P Morimoto Richard I RI Dobson Christopher M CM Vendruscolo Michele M Mann Matthias M Hartl F Ulrich FU

Cell 20150501 4

Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during aging, resulting in a severe proteome imbalance. These changes are reduced in the long-lived daf-2 mutant but are enhanced in the short-lived daf-16 mutant. While ribosomal proteins de ...[more]

PMID: 25957690

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Widespread Proteome Remodeling and Aggregation in Aging C. elegans

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