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Omics score: 1007

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD001500. Experiment: IFNAR_KO_Prog_78a, file: 120503_JH_IFNAR_KO_Prog_78a_10.mzml. Published as part of Cell Stem Cell. 2015 Aug 19. pii: S1934-5909(15)00306-9 . From the Abstract: {{i}} ... Here, we report that the phenotypic hematopoietic stem cell (HSC) compartment contains stem-like megakaryocyte-committed progenitors (SL-MkPs), a cell population that shares many features with multipotent HSCs and serves as a lineage-restricted emergency pool for inflammatory insults ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Mus_musculus_viruses, Mouse

DISEASE(S): Not Available

SUBMITTER: Haas S, et al.

PROVIDER: GPM32310023393 | GPMDB |

REPOSITORIES: GPMDB

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Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

Haas Simon S Hansson Jenny J Klimmeck Daniel D Loeffler Dirk D Velten Lars L Uckelmann Hannah H Wurzer Stephan S Prendergast Áine M ÁM Schnell Alexandra A Hexel Klaus K Santarella-Mellwig Rachel R Blaszkiewicz Sandra S Kuck Andrea A Geiger Hartmut H Milsom Michael D MD Steinmetz Lars M LM Schroeder Timm T Trumpp Andreas A Krijgsveld Jeroen J Essers Marieke A G MA

Cell stem cell 20150820 4

Infections are associated with extensive platelet consumption, representing a high risk for health. However, the mechanism coordinating the rapid regeneration of the platelet pool during such stress conditions remains unclear. Here, we report that the phenotypic hematopoietic stem cell (HSC) compartment contains stem-like megakaryocyte-committed progenitors (SL-MkPs), a cell population that shares many features with multipotent HSCs and serves as a lineage-restricted emergency pool for inflammat ...[more]

PMID: 26299573

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