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Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects beta-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD001514. File: CSF124WT_50cm_TR1.mzml. Published as part of Mol Cell Proteomics. 2015 Oct;14(10):2550-63 . From the Abstract: {{i}} ... We demonstrate that the CSF proteome of individual mice can be analyzed in a quantitative manner to a depth of several hundred proteins in a robust and simple workflow consisting of single ultra HPLC runs on a benchtop mass spectrometer ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Mus_musculus_viruses, Mouse

DISEASE(S): Not Available

SUBMITTER: Dislich B, et al.  

PROVIDER: GPM32310025075 | GPMDB |

REPOSITORIES: GPMDB

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Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.

Dislich Bastian B   Wohlrab Felix F   Bachhuber Teresa T   Müller Stephan A SA   Kuhn Peer-Hendrik PH   Hogl Sebastian S   Meyer-Luehmann Melanie M   Lichtenthaler Stefan F SF  

Molecular & cellular proteomics : MCP 20150702 10

Analysis of murine cerebrospinal fluid (CSF) by quantitative mass spectrometry is challenging because of low CSF volume, low total protein concentration, and the presence of highly abundant proteins such as albumin. We demonstrate that the CSF proteome of individual mice can be analyzed in a quantitative manner to a depth of several hundred proteins in a robust and simple workflow consisting of single ultra HPLC runs on a benchtop mass spectrometer. The workflow is validated by a comparative ana  ...[more]

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