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Omics score: 1004

JUMP: a tag-based database search tool for peptide identification with high sensitivity and accuracy.

ABSTRACT: Data from authors [[http://stjuderesearch.org/site/lab/peng web site]]. Experiment: dataset3, file: pl08.mzXML. Published as part of Mol Cell Proteomics. 2014 Sep 8 . From the Abstract: {{i}} ... Here we present JUMP, a new hybrid database search program that generates amino acid tags and ranks peptide spectrum matches (PSMs) by an integrated score from the tags and pattern matching. In a typical run of liquid chromatography coupled with high-resolution tandem MS, more than 95% of MS/MS spectra can generate at least one tag, whereas the remaining spectra are usually too poor to derive genuine PSMs ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Homo_sapiens_viruses, Human

DISEASE(S): Not Available

SUBMITTER: Wang X, et al.

PROVIDER: GPM32320003491 | GPMDB |

REPOSITORIES: GPMDB

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JUMP: a tag-based database search tool for peptide identification with high sensitivity and accuracy.

Wang Xusheng X Li Yuxin Y Wu Zhiping Z Wang Hong H Tan Haiyan H Peng Junmin J

Molecular & cellular proteomics : MCP 20140908 12

Database search programs are essential tools for identifying peptides via mass spectrometry (MS) in shotgun proteomics. Simultaneously achieving high sensitivity and high specificity during a database search is crucial for improving proteome coverage. Here we present JUMP, a new hybrid database search program that generates amino acid tags and ranks peptide spectrum matches (PSMs) by an integrated score from the tags and pattern matching. In a typical run of liquid chromatography coupled with hi ...[more]

PMID: 25202125

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