Quantitative proteomics of human NPC1I1061T (sic) mutant fibroblasts provides insights into the pathogenesis of Niemann-Pick Type C disease.

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD001938. Experiment: WTvsI1061T_TMT_inj01, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Apr 14 . From the Abstract: {{i}} In our study, an isobaric labeling based quantitative analysis of proteome of NPC1I1061T (sic) primary fibroblasts when compared to wild-type cells identified 281 differentially expressed proteins based on stringent data analysis criteria. Gene ontology enrichment analysis revealed that these proteins play important roles in diverse cellular processes such as protein maturation, energy metabolism, metabolism of reactive oxygen species, antioxidant activity, steroid metabolism, lipid localization, and apoptosis. {{/i}} Cell types: GM18453 (NPC1:p.I1061T) and GM05659 (wt).

INSTRUMENT(S): Instrument

ORGANISM(S): Homo_sapiens_viruses, Human

DISEASE(S): Not Available

SUBMITTER: Rauniyar N, et al.  

PROVIDER: GPM32320014822 | GPMDB |

REPOSITORIES: GPMDB