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Comprehensive temporal protein dynamics during the diauxic shift in Saccharomyces cerevisiae

ABSTRACT: Data from ProteomeXchange, PXD ID: PXD001338. File: Hap2_fraction_5.mzml. Published as part of Mol Cell Proteomics. 2015 Jun 15 . From the Abstract: {{i}} Yeast (Saccharomyces cerevisiae) has served as a key model system in biology and as a benchmark for omics technology. Although near-complete proteomes of log phase yeast have been measured, protein abundance in yeast is dynamic, particularly during the transition from log to stationary phase. Defining the dynamics of proteomic changes during this transition, termed the diauxic shift, is important to understand the basic biology of proliferative versus quiescent cells. Here, we perform temporal quantitative proteomics to fully capture protein induction and repression during the diauxic shift ... {{/i}}

INSTRUMENT(S): Instrument

ORGANISM(S): Yeast

DISEASE(S): Not Available

SUBMITTER: Murphy JP, et al.  

PROVIDER: GPM32320015932 | GPMDB |

REPOSITORIES: GPMDB

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Comprehensive Temporal Protein Dynamics during the Diauxic Shift in Saccharomyces cerevisiae.

Murphy J Patrick JP   Stepanova Ekaterina E   Everley Robert A RA   Paulo Joao A JA   Gygi Steven P SP  

Molecular & cellular proteomics : MCP 20150615 9

Yeast (Saccharomyces cerevisiae) has served as a key model system in biology and as a benchmark for "omics" technology. Although near-complete proteomes of log phase yeast have been measured, protein abundance in yeast is dynamic, particularly during the transition from log to stationary phase. Defining the dynamics of proteomic changes during this transition, termed the diauxic shift, is important to understand the basic biology of proliferative versus quiescent cells. Here, we perform temporal  ...[more]