The role of ptpn21 in hematopoietic stem cells

ABSTRACT: To identify the downstream substrate/effector that mediates Ptpn21 function. We applied comprehensive phosphoproteomics analysis with Lin- cells isolated from Ptpn21-/- and Ptpn21+/+ mice. The analysis revealed many pTyr sites on molecules associated with cytoskeleton. Additionally, we present a list of Ptpn21-dependent targets and putative substrates including Septin1 with increased tyrosine phosphorylation.

ORGANISM(S): Mus Musculus

SUBMITTER: Chengkui Qu  

PROVIDER: PXD011381 | iProX | Wed Oct 17 00:00:00 GMT+01:00 2018

REPOSITORIES: iProX