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Identification of proteins associated with IFN-γR2 in macrophages

ABSTRACT: Department of Immunology & Center for Immunotherapy

ORGANISM(S): Mus Musculus

SUBMITTER: Xuetao Cao

PROVIDER: PXD011572 | iProX | Thu Oct 25 00:00:00 BST 2018

REPOSITORIES: iProX

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Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response.

Xu Xiaoqing X Xu Jia J Wu Jiacheng J Hu Ye Y Han Yanmei Y Gu Yan Y Zhao Kai K Zhang Qian Q Liu Xingguang X Liu Juan J Liu Bing B Cao Xuetao X

Cell 20181011 5

As a critical step during innate response, the cytoplasmic β subunit (IFN-γR2) of interferon-γ receptor (IFN-γR) is induced and translocates to plasma membrane to join α subunit to form functional IFN-γR to mediate IFN-γ signaling. However, the mechanism driving membrane translocation and its significance remain largely unknown. We found, unexpectedly, that mice deficient in E-selectin, an endothelial cell-specific adhesion molecule, displayed impaired innate activation of macrophages upon Liste ...[more]

PMID: 30318148

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