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Integrative analysis of microRNAome, transcriptome, and proteome during the limb regeneration of Cynops orientalis

ABSTRACT: Salamanders completely regenerate their limbs after amputation. Thus, these animals are unique models to investigate the mechanisms modulating the regeneration in vertebrates. To investigate the influence of microRNAs on the newt limb regeneration, an integrative analysis of microRNAome, transcriptome, and proteome were performed.

ORGANISM(S): Cynops Orientalis

SUBMITTER: Fulin Chen

PROVIDER: PXD012091 | iProX | Mon Dec 17 00:00:00 GMT 2018

REPOSITORIES: iProX

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Integrative Analysis of MicroRNAome, Transcriptome, and Proteome during the Limb Regeneration of Cynops orientalis.

Yu Yuan Y Tang Jie J Su Jiaojiao J Cui Jihong J Xie Xin X Chen Fulin F

Journal of proteome research 20190117 3

Salamanders completely regenerate their limbs after amputation. Thus, these animals are unique models to investigate the mechanisms modulating regeneration in vertebrates. To investigate the influence of microRNAs (miRNAs) on newt limb regeneration, the miRNAs and mRNAs were simultaneously profiled using Illumina HiSeq 2500 System during limb regeneration of Cynops orientalis at 3, 7, 14, 30 and 42 days postamputation. A total of 203 miRNAs and 4230 mRNAs were identified to be differentially exp ...[more]

PMID: 30608709

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