Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus Norvegicus
SUBMITTER: Xue Yu
PROVIDER: PXD012196 | iProX | Sun Dec 01 00:00:00 GMT 2019
REPOSITORIES: iProX
Ruan Chen C Wang Chenwei C Gong Xuanqing X Zhang Ying Y Deng Wankun W Zhou Jiaqi J Huang Dengtong D Wang Zining Z Zhang Qiong Q Guo Anyuan A Lu Jiahong J Gao Jinhao J Peng Di D Xue Yu Y
Autophagy 20200523 6
Dysfunction of macroautophagy/autophagy has been postulated as a major cellular toxicological response to nanomaterials. It has been reported that excessive autophagy activation, induced by silica nanoparticles (SiNPs), contributes to autophagy dysfunction, whereas little is known how SiNPs trigger autophagy activation. Here, we treated normal rat kidney (NRK) cells using 3 different sizes of SiNPs (16, 29, and 51 nm) and observed that 16-nm SiNPs, with a final concentration of 60 μg/mL, dramati ...[more]