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Distinctive metabolic features of seminoma and embryonic carcinoma revealed by combined transcriptome and metabolomics analyses

ABSTRACT: Using well-characterized cell line models for seminoma (Tcam-2, n=15) and EC (NT2, n=15), we characterized their metabolite profiles using ultraperformance liquid chromatography coupled with Q-TOF mass spectrometry (UPLC/Q-TOF MS).

ORGANISM(S): Homo Sapiens

SUBMITTER: Suren Chen

PROVIDER: PXD012313 | iProX | Sat Jan 12 00:00:00 GMT 2019

REPOSITORIES: iProX

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Distinct Metabolic Features of Seminoma and Embryonal Carcinoma Revealed by Combined Transcriptome and Metabolome Analyses.

Batool Aalia A Chen Su-Ren SR Liu Yi-Xun YX

Journal of proteome research 20190312 4

Seminoma and embryonal carcinoma (EC), two typical types of testicular germ cell tumors (TGCTs), present significant differences in growth behavior, expression characteristics, differentiation potential, clinical features, therapy, and prognosis. The purpose of this study was to compare the distinctive or preference metabolic pathways between seminoma and EC. The Cancer Genome Atlas revealed that many genes encoding metabolic enzymes could distinguish between seminoma and EC. Using well-characte ...[more]

PMID: 30835130

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