Proteomics

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Proteogenomic characterization analysis of human large cell lung cancer

ABSTRACT: Current clinical therapy of non-small cell lung cancer depends on histo-pathological classification. This approach poorly predicts clinical outcome for individual patients. Proteogenomic characterization analysis holds promise to improve clinical stratification, thus paving the way for individualized therapy. We investigated proteogenomic characterization and performed comprehensive integrative genomic analysis of human large cell lung cancer. Here we analyzed proteomes of 29 paired normal lung tissues and large cell lung cancer, identified significantly deregulated proteins associated with large cell lung cancer.

ORGANISM(S): Homo Sapiens

SUBMITTER: Da Fu  

PROVIDER: PXD012393 | iProX | Wed Jan 16 00:00:00 GMT 2019

REPOSITORIES: iProX

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Bie-Jia-Ruan-Mai-Tang, a Chinese Medicine Formula, Inhibits Retinal Neovascularization in Diabetic Mice Through Inducing the Apoptosis of Retinal Vascular Endothelial Cells.

Liu Qiu-Ping QP   Chen Yu-Ying YY   Yu Yuan-Yuan YY   An Pei P   Xing Yi-Zhuo YZ   Yang Hong-Xuan HX   Zhang Yin-Jian YJ   Rahman Khalid K   Zhang Lei L   Luan Xin X   Zhang Hong H  

Frontiers in cardiovascular medicine 20220712

Proliferative diabetic retinopathy (PDR) is one of the main complications of diabetes, mainly caused by the aberrant proliferation of retinal vascular endothelial cells and the formation of new blood vessels. Traditional Chinese medicines possess great potential in the prevention and treatment of PDR. Bie-Jia-Ruan-Mai-Tang (BJ), a Chinese medicine formula, has a good therapeutic effect on PDR clinically; however, the mechanism of action involved remains unclear. Therefore, we investigated the ef  ...[more]

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