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Integrated tear proteome and metabolome reveal panels of inflammatory-related molecules via key regulatory pathways in dry eye syndrome

ABSTRACT: We applied nanoscale liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (nanoLC/Q-TOF-MS/MS) and ultra-performance LC/Q-TOF-MS/MS technologies on tear samples obtained from 18 dry eye patients and 19 healthy controls for integrated proteomic and metabolomic analyses

ORGANISM(S): Homo Sapiens

SUBMITTER: XingHuai Sun

PROVIDER: PXD012917 | iProX | Thu Feb 28 00:00:00 GMT 2019

REPOSITORIES: iProX

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Integrated Tear Proteome and Metabolome Reveal Panels of Inflammatory-Related Molecules via Key Regulatory Pathways in Dry Eye Syndrome.

Chen Xueli X Rao Jun J Zheng Zhi Z Yu Yan Y Lou Shang S Liu Liping L He Qinsi Q Wu Luhua L Sun Xinghuai X Sun Xinghuai X

Journal of proteome research 20190416 5

Dry eye syndrome (DES) is a growing public health concern with a high global prevalence; however, the fundamental processes involved in its pathogenic mechanisms remain poorly understood. In the present study, we applied nanoscale liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (nanoLC/Q-TOF-MS/MS) and ultraperformance LC/Q-TOF-MS/MS technologies on tear samples obtained from 18 dry eye patients and 19 healthy controls for integrated proteomic and metabolomic analyse ...[more]

PMID: 30966751

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