Proteomics

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Comparative proteomic investigation of plasma reveals novel potential biomarker groups for acute aortic dissection

ABSTRACT: Acute aortic dissection (AAD) is a catastrophic cardiovascular disease with high disability and mortality due to multiple fatal complications. However, the molecular changes of serum proteome after AAD are not very clear. Here, we performed isobaric tags for relative and absolute quantitation (iTRAQ) based comparative proteomic analysis to investigate the proteome profile changes after AAD by collecting serum samples from 20 AAD patients and 20 controls.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhen Chen  

PROVIDER: PXD013465 | iProX | Thu Apr 11 00:00:00 BST 2019

REPOSITORIES: iProX

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Comparative Proteomic Investigation of Plasma Reveals Novel Potential Biomarker Groups for Acute Aortic Dissection.

Cheng Na N   Wang Hao H   Zhang Weizong W   Wang Heng H   Jin Xiang X   Ma Xiang X   Ma Yitong Y  

Disease markers 20200318

Acute aortic dissection (AAD) is a catastrophic cardiovascular disease with high disability and mortality due to multiple fatal complications. However, the molecular changes of the serum proteome after AAD are not very clear. Here, we performed isobaric tags for relative and absolute quantitation- (iTRAQ-) based comparative proteomic analysis to investigate the proteome profile changes after AAD by collecting plasma samples from 20 AAD patients and 20 controls. Out of the 345 identified proteins  ...[more]

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