Mouse liver concatenated tandem array of consensus TF response elements (catTFRE) with H2O2
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Depei Liu
PROVIDER: PXD015265 | iProX | Sat Aug 31 00:00:00 BST 2019
REPOSITORIES: iProX
Publications
Diurnal oscillations of endogenous H<sub>2</sub>O<sub>2</sub> sustained by p66<sup>Shc</sup> regulate circadian clocks.
Pei Jian-Fei JF Li Xun-Kai XK Li Wen-Qi WQ Gao Qian Q Zhang Yang Y Wang Xiao-Man XM Fu Jia-Qi JQ Cui Shen-Shen SS Qu Jia-Hua JH Zhao Xiang X Hao De-Long DL Ju Dapeng D Liu Na N Carroll Kate S KS Yang Jing J Zhang Eric Erquan EE Cao Ji-Min JM Chen Hou-Zao HZ Liu De-Pei DP
Nature cell biology 20191125 12
Redox balance, an essential feature of healthy physiological steady states, is regulated by circadian clocks, but whether or how endogenous redox signalling conversely regulates clockworks in mammals remains unknown. Here, we report circadian rhythms in the levels of endogenous H<sub>2</sub>O<sub>2</sub> in mammalian cells and mouse livers. Using an unbiased method to screen for H<sub>2</sub>O<sub>2</sub>-sensitive transcription factors, we discovered that rhythmic redox control of CLOCK directl ...[more]
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