Label-free quantitative proteomic analysis of rat liver tissue

ABSTRACT: In this study, the spleen deficiency syndrome rat model was built with reserpine injection method. At first, the intervention effect of SJZD on spleen deficiency syndrome was preliminary evaluation through pharmacodynamics study. By comparing the differences proteins of liver tissues by label-free proteomics techniques, the differentially expressed proteins of spleen deficiency syndrome and SJZD intervention spleen deficiency syndrome were screened. At last, differentially expressed proteins were analyzed with bioinformatics analysis method, the potential target proteins of spleen deficiency syndrome and SJZD intervention spleen deficiency syndrome were excavated. At the same time, the corresponding metabolic pathways and biological molecular interaction network was established. We hope to probe the mechanisms of SJZD intervention spleen deficiency syndrome from the aspect of proteomic to provide a scientific basis for the clinical diagnosis and treatment of spleen deficiency syndrome.

ORGANISM(S): Rattus Rattus

SUBMITTER: Qinghua Yan  

PROVIDER: PXD015449 | iProX | Sat Sep 14 00:00:00 BST 2019

REPOSITORIES: iProX