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Hippocampal proteomics of CMS-treated rats

ABSTRACT: We used a chronic mild stress (CMS) protocol to separate susceptible-depression, susceptible-anxiety and insusceptible rat subgroups. Differential proteomes in the hippocampus were analyzed based on isobaric tags for relative and absolute quantitation (iTRAQ) labeling combined with mass spectrometry.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Jian Zhou

PROVIDER: PXD015946 | iProX | Mon Oct 21 00:00:00 BST 2019

REPOSITORIES: iProX

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Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress.

Tang Min M Huang Haojun H Li Shuiming S Zhou Mi M Liu Zhao Z Huang Rongzhong R Liao Wei W Xie Peng P Zhou Jian J

Translational psychiatry 20191017 1

Chronic stressful occurrences are documented as a vital cause of both depression and anxiety disorders. However, the stress-induced molecular mechanisms underlying the common and distinct pathophysiology of these disorders remains largely unclear. We utilized a chronic mild stress (CMS) rat model to differentiate and subgroup depression-susceptible, anxiety-susceptible, and insusceptible rats. The hippocampus was analyzed for differential proteomes by combining mass spectrometry and the isobaric ...[more]

PMID: 31624233

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