Protein Lysine 43 Methylation by EZH1 Promotes AML1-ETO Transcriptional Repression
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Shujun Liu
PROVIDER: PXD016712 | iProX | Wed Dec 11 00:00:00 GMT 2019
REPOSITORIES: iProX
Publications
Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia.
Dou Liping L Yan Fei F Pang Jiuxia J Zheng Dehua D Li Dandan D Gao Li L Wang Lijun L Xu Yihan Y Shi Jinlong J Wang Qian Q Zhou Lei L Shen Na N Singh Puja P Wang Lili L Li Yonghui Y Gao Yvchi Y Liu Tao T Chen Chongjian C Al-Kali Aref A Litzow Mark R MR Chi Young-In YI Bode Ann M AM Liu Chunhui C Huang Haojie H Liu Daihong D Marcucci Guido G Liu Shujun S Yu Li L
Nature communications 20191107 1
The oncogenic fusion protein AML1-ETO retains the ability of AML1 to interact with the enhancer core DNA sequences, but blocks AML1-dependent transcription. Previous studies have shown that post-translational modification of AML1-ETO may play a role in its regulation. Here we report that AML1-ETO-positive patients, with high histone lysine methyltransferase Enhancer of zeste homolog 1 (EZH1) expression, show a worse overall survival than those with lower EZH1 expression. EZH1 knockdown impairs s ...[more]
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