Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Minjia Tan
PROVIDER: PXD016779 | iProX | Tue Dec 17 00:00:00 GMT 2019
REPOSITORIES: iProX
Hao Bingbing B Sun Mingwei M Zhang Min M Zhao Xiaoxiao X Zhao Lei L Li Bolin B Zhai Linhui L Liu Ping P Hu Hao H Xu Jun-Yu JY Tan Minjia M
Journal of proteomics 20191214
Lysine methylation is a widespread protein post-translational modification showing essentialities in versatile cellular process. EZH2, a methyltransferase specifically trimethylates the lysine 27 of histone H3 and its aberrance in several cancers promotes the development of its inhibitors against hematological tumors. In this study, we presented a deep exploration of lysine mono-, di- and trimethylomes in EZH2 wild-type and Y641 mutant lymphoma cell lines. Our results showed that several substra ...[more]