Dataset Information
Co-IP and LC-MS/MS analysis for probing the binding partners of ITGBL1 in fibroblasts
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Qi Li
PROVIDER: PXD017182 | iProX | Sun Jan 19 00:00:00 GMT 2020
REPOSITORIES: iProX
Publications
Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation.
Nature communications 20200305 1
Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal tissues and organs in their dormant state. Mechanisms underlying the pre-metastatic niche formation are poorly understood. Here we show that in a colorectal cancer (CRC) model, primary tumors release integrin beta-like 1 (ITGBL1)-rich extracellular vesicles (EVs) to the circulation to activate resident fibroblasts in remote organs. The activated fibroblasts induce the pre-metastatic niche formation and promo ...[more]
