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Proteomics analysis in normal and blue light-exposed ARPE-19 cells

ABSTRACT: Proteomics analysis to identify the differential expression of proteins in normal and blue light-exposed ARPE-19 cells

ORGANISM(S): Homo Sapiens

SUBMITTER: Ping Gu

PROVIDER: PXD017259 | iProX | Wed Jan 22 00:00:00 GMT 2020

REPOSITORIES: iProX

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Protection against light-induced retinal degeneration via dual anti-inflammatory and anti-angiogenic functions of thrombospondin-1.

Ju Yahan Y Tang Zhimin Z Dai Xiaochan X Gao Huiqin H Zhang Jing J Liu Yan Y Yang Yanan Y Ni Ni N Zhang Dandan D Wang Yuyao Y Sun Na N Yin Luqiao L Luo Min M Zhang Jianhua J Gu Ping P

British journal of pharmacology 20201218 9

<h4>Background and purpose</h4>Retinal photodamage is a high-risk factor for age-related macular degeneration (AMD), the leading cause of irreversible blindness worldwide. However, both the pathogenesis and effective therapies for retinal photodamage are still unclear and debated.<h4>Experimental approach</h4>The anti-inflammatory effects of thrombospondin-1 on blue light-induced inflammation in ARPE-19 cells and in retinal inflammation were evaluated. Furthermore, the anti-angiogenic effects of ...[more]

PMID: 33125704

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