Proteomics

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Asymmetric dimethylarginine proteome of pancreatic ductal adenocarcinoma.

ABSTRACT: Protein arginine methylation has been established an essential protein modification regulating cancer initiation and progression, but its implications in PDAC (Pancreatic ductal adenocarcinoma) still remains poorly elucidated. In this study, we characterized ADMA (asymmetric dimethylarginine)-bearing peptides in human pancreatic ductal epithelium cell line HPDE6c7 and PDAC cell line PANC-1 by a label-free quantitative proteomics combined with affinity purification.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jiliang Hu  

PROVIDER: PXD017577 | iProX | Tue Feb 18 00:00:00 GMT 2020

REPOSITORIES: iProX

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Proteome-Wide Alterations of Asymmetric Arginine Dimethylation Associated With Pancreatic Ductal Adenocarcinoma Pathogenesis.

Wei Meijin M   Tan Chaochao C   Tang Zhouqin Z   Lian Yingying Y   Huang Ying Y   Chen Yi Y   Chen Congwei C   Zhou Wen W   Cai Tao T   Hu Jiliang J  

Frontiers in cell and developmental biology 20201203

Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) performs essential roles in regulating cancer initiation and progression, but its implication in pancreatic ductal adenocarcinoma (PDAC) requires further elucidation. In this study, asymmetric dimethylarginine (ADMA)-containing peptides in PDAC cell line PANC-1 were identified by label-free quantitative proteomics combined with affinity purification, using human non-cancerous pancreatic ductal epithelium cell line HPDE  ...[more]

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