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Differential Mitochondrial proteomics analysis of A549 cells infected with H5 and H9 subtypes of avian influenza viruses

ABSTRACT: The temporal response of primary human alveolar adenocarcinoma epithelial cells (A549) infected with H5N1 influenza virus and H9N2 influenza A viruswere evaluated using the proteomics approaches (2D-DIGE combined with MALDI-TOF-MS/MS) at 24 hours post of the infection .

ORGANISM(S): Homo Sapiens

SUBMITTER: Ze Chen

PROVIDER: PXD017921 | iProX | Fri Mar 06 00:00:00 GMT 2020

REPOSITORIES: iProX

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Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9.

Yang Yuting Y Zhang Yun Y Yang Changcheng C Fang Fang F Wang Ying Y Chang Haiyan H Chen Ze Z Chen Ping P

Virology journal 20210218 1

<h4>Background</h4>Both the highly pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H9N2 viruses have been reported to cross species barriers to infect humans. H5N1 viruses can cause severe damage and are associated with a high mortality rate, but H9N2 viruses do not cause such outcomes. Our purpose was to use proteomics technology to study the differential expression of mitochondrial-related proteins related to H5N1 and H9N2 virus infections.<h4>Methods</h4>Accor ...[more]

PMID: 33602268

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