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Multi-omics analysis of natural aging mouse liver

ABSTRACT: Multi-omics analysis is relatively rare in aging research and has not been used for aging liver study by now. Here, we performed metabolome, proteome and acetylome with livers of 2-month-old and 18-month-old mice.

ORGANISM(S): Mus Musculus

SUBMITTER: Juntao Yang

PROVIDER: PXD018003 | iProX | Wed Mar 11 00:00:00 GMT 2020

REPOSITORIES: iProX

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[Proteome and Acetylome Profiling of Livers in C57BL/6J Male Mice during Normal Aging].

Liu Jiang-Feng JF Yang Ye-Hong YH Wu Yue Y Yang Jun-Tao JT

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20211001 5

Objective To obtain the proteome and acetylome profiles of livers in mice during normal aging.Methods We applied tandem mass tag labeling and liquid chromatography tandem mass spectrometry and achieved proteome and acetylome data in C57BL/6J male mice aged 2 and 18 months under physiological conditions.Results A total of 4712 proteins were quantified by proteome profiling,and 4818 acetylated sites in 1367 proteins by acetylome profiling.The proteome and acetylome revealed moderate differences in ...[more]

PMID: 34728030

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