Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells

ABSTRACT: m6A is the most abundant modification of mRNA in mammals and plays an important role in human development and disease. METTL14 is a key component of m6A methyltransferase complex. The project showed that its post-translational arginine methylation can regulate the generation of m6A and the endoderm differentiation of mouse embryonic stem cells, indicating its essential function in the normal development of embryos.

ORGANISM(S): Homo Sapiens

SUBMITTER: Shan Xiao  

PROVIDER: PXD018458 | iProX | Mon May 17 00:00:00 GMT+01:00 2021

REPOSITORIES: iProX