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Protein identification of purpureomaculin isolated from Malaysian mangrove pit viper (Trimeresurus purpureomaculatus)

ABSTRACT: Identification of purpureomaculin using nano-ESI-LCMS/MS

ORGANISM(S): Trimeresurus Purpureomaculatus

SUBMITTER: Choo Hock Tan

PROVIDER: PXD018463 | iProX | Mon Apr 13 00:00:00 BST 2020

REPOSITORIES: iProX

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Cytotoxic and anticancer properties of the Malaysian mangrove pit viper (<i>Trimeresurus purpureomaculatus</i>) venom and its disintegrin (purpureomaculin).

Tan Choo Hock CH Liew Jia Lee JL Navanesan Suerialoasan S Sim Kae Shin KS Tan Nget Hong NH Tan Kae Yi KY

The journal of venomous animals and toxins including tropical diseases 20200717

<h4>Background</h4>The Asiatic pit vipers from the <i>Trimeresurus</i> complex are medically important venomous snakes. These pit vipers are often associated with snakebite that leads to fatal coagulopathy and tissue necrosis. The cytotoxic venoms of <i>Trimeresurus</i> spp.; however, hold great potential for the development of peptide-based anticancer drugs.<h4>Methods</h4>This study investigated the cytotoxic effect of the venom from <i>Trimeresurus purpureomaculatus</i>, the mangrove pit vipe ...[more]

PMID: 32742279

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