Myeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity

ABSTRACT: In this study, we found that myeloid PTEN can determine chemotherapy responsiveness by promoting NLRP3-dependent antitumor immunity and suggest that it might be a potential biomarker to predict the chemotherapy responses and manipulating NLRP3/IL-1might be able to overcome the chemotherapy resistance in PTEN-loss patients.

ORGANISM(S): Homo Sapiens

SUBMITTER: Rongbin Zhou  

PROVIDER: PXD018597 | iProX | Thu Apr 16 00:00:00 BST 2020

REPOSITORIES: iProX