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Proteomics profiling of placental tissues from placenta accreta and control pregnancies

ABSTRACT: Placenta accreta is a major cause of maternal morbidity and mortality in modern obstetrics. The study aims to identify the differently expressed proteins in placenta accreta patients compared with controls and to determine biological pathways, which provides a novel insight into the pathogenesis of placneta accreta.

ORGANISM(S): Homo Sapiens

SUBMITTER: Caixia Liu

PROVIDER: PXD018665 | iProX | Sun Apr 19 00:00:00 BST 2020

REPOSITORIES: iProX

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Integration of transcriptome and proteome profiles in placenta accreta reveals trophoblast over-migration as the underlying pathogenesis.

Li Na N Hou Rui R Liu Caixia C Yang Tian T Qiao Chong C Wei Jun J

Clinical proteomics 20211229 1

<h4>Background</h4>Placenta accreta (PA) is a major cause of maternal morbidity and mortality in modern obstetrics, few studies have explored the underlying molecular mechanisms.<h4>Methods</h4>In our study, transcriptome and proteome profiling were performed in placental tissues from ten participants including five cases each in the PA and control groups to clarify the pathogenesis of PA.<h4>Results</h4>We identified differential expression of 37,743 transcripts and 160 proteins between the PA ...[more]

PMID: 34963445

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RNA sequencing profiling of placental tissues from placenta accreta and control pregnancies

Project description:Placenta accreta is a major cause of maternal morbidity and mortality in modern obstetrics. The study aims to identify the differently expressed lncRNA and mRNA in placenta accreta patients compared with controls and to determine biological pathways, which provides a novel insight ingto thepathogenesis of placneta accreta.

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Timecourse of developing mouse placenta, with placental and decidual tissues profiled separately

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microRNA array analysis of HTR-8/Svneo cells with BHLHE40 knockdown or not.

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