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Acetylome Analysis of Feline Small Intestine Following Toxoplasma gondii Infection

ABSTRACT: Toxoplasma gondii threats to the health of one-third of the world's population. Cat is the natural definite host of T. gondii. However, the biological changes of feline small intestine following T. gondii infection remains mysterious event. Protein acetylation modification which is a dynamic and reversible post-translational modification (PTM) plays important roles in regulating various physiological functions. In this study, we used affinity enrichment and high resolution LC-MS/MS to analyze the alteration of acetylation event in feline small intestine infected by Prugniuad (Pru) strain of Toxoplasma gondii.

ORGANISM(S): Felis Catus

SUBMITTER: Xingquan Zhu

PROVIDER: PXD018799 | iProX | Thu Jul 09 00:00:00 BST 2020

REPOSITORIES: iProX

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Acetylome analysis of the feline small intestine following Toxoplasma gondii infection.

Meng Yu-Meng YM Zhai Bin-Tao BT Elsheikha Hany M HM Xie Shi-Chen SC Wang Ze-Xiang ZX Zhao Quan Q Zhu Xing-Quan XQ He Jun-Jun JJ

Parasitology research 20200920 11

Toxoplasma gondii is a protozoan parasite capable of infecting a large number of warm-blooded animals and causes serious health complications in immunocompromised patients. T. gondii infection of the feline small intestine is critical for the completion of the life cycle and transmission of T. gondii. Protein acetylation is an important posttranslational modification, which plays roles in the regulation of various cellular processes. Therefore, understanding of how T. gondii reprograms the prote ...[more]

PMID: 32951143

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